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Koji Abe Selected Research

Hypertension (High Blood Pressure)

6/2015Protective effect of telmisartan on neurovascular unit and inflammasome in stroke-resistant spontaneously hypertensive rats.
4/2015Long-term effect of telmisartan on Alzheimer's amyloid genesis in SHR-SR after tMCAO.
3/2015Neurovascular protection by telmisartan via reducing neuroinflammation in stroke-resistant spontaneously hypertensive rat brain after ischemic stroke.
11/2014Telmisartan reduces progressive accumulation of cellular amyloid beta and phosphorylated tau with inflammatory responses in aged spontaneously hypertensive stroke resistant rat.
11/2014Telmisartan ameliorates inflammatory responses in SHR-SR after tMCAO.
11/2014Long-term amelioration of telmisartan on metabolic syndrome-related molecules in stroke-resistant spontaneously hypertensive rat after transient middle cerebral artery occlusion.
10/2014Strong reduction of low-density lipoprotein receptor/apolipoprotein E expressions by telmisartan in cerebral cortex and hippocampus of stroke resistant spontaneously hypertensive rats.
7/2014Telmisartan reduces progressive oxidative stress and phosphorylated α-synuclein accumulation in stroke-resistant spontaneously hypertensive rats after transient middle cerebral artery occlusion.
7/2014Protective effect of telmisartan against progressive oxidative brain damage and synuclein phosphorylation in stroke-resistant spontaneously hypertensive rats.
1/2012Mechanisms of endogenous endothelial repair in stroke.
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Koji Abe Research Topics

Disease

62Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
01/2023 - 10/2002
55Stroke (Strokes)
01/2023 - 03/2005
54Alzheimer Disease (Alzheimer's Disease)
03/2024 - 05/2002
42Ischemic Stroke
03/2024 - 12/2004
41Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
03/2024 - 11/2003
41Infarction (Infarctions)
01/2023 - 11/2003
39Brain Ischemia (Cerebral Ischemia)
11/2023 - 10/2002
26Ischemia
03/2024 - 04/2002
22Dementia (Dementias)
12/2022 - 03/2002
14Inflammation (Inflammations)
01/2023 - 01/2011
13Cerebral Infarction
03/2024 - 03/2005
12Cognitive Dysfunction
12/2022 - 01/2011
12Neuroinflammatory Diseases
12/2022 - 01/2011
12Hypoxia (Hypoxemia)
06/2020 - 11/2003
11Neoplasms (Cancer)
01/2023 - 12/2005
11Parkinson Disease (Parkinson's Disease)
12/2020 - 01/2002
11Metabolic Syndrome (Dysmetabolic Syndrome X)
06/2015 - 01/2011
11Hypertension (High Blood Pressure)
06/2015 - 03/2011
10Spinal Cord Ischemia
11/2015 - 02/2003
8Atrophy
06/2021 - 01/2014
8Disease Progression
11/2020 - 01/2002
8Brain Injuries (Brain Injury)
10/2016 - 05/2004
6Neurodegenerative Diseases (Neurodegenerative Disease)
03/2024 - 12/2007
6Transient Ischemic Attack
01/2019 - 06/2011
6Parkinsonian Disorders (Parkinsonism)
08/2018 - 12/2003
5Prion Diseases (Transmissible Spongiform Encephalopathies)
12/2022 - 10/2010
5Pathologic Constriction (Stenosis)
10/2019 - 01/2016
5Breast Neoplasms (Breast Cancer)
01/2018 - 01/2009
5Spinocerebellar Ataxias (Spinocerebellar Ataxia)
09/2017 - 01/2007
5Amyloid Plaque
04/2015 - 01/2011
5Brain Edema (Cerebral Edema)
08/2011 - 11/2003
4Spinal Cord Injuries (Spinal Cord Injury)
01/2021 - 11/2003
4Thrombosis (Thrombus)
01/2021 - 01/2014
4Muscle Weakness
06/2020 - 12/2013
4Deglutition Disorders (Dysphagia)
03/2020 - 01/2014
4Frontotemporal Dementia (Semantic Dementia)
01/2020 - 02/2005

Drug/Important Bio-Agent (IBA)

50Proteins (Proteins, Gene)FDA Link
03/2020 - 10/2002
28EdaravoneIBA
03/2024 - 11/2003
27Neuroprotective AgentsIBA
03/2024 - 05/2004
23Amyloid (Amyloid Fibrils)IBA
12/2022 - 09/2002
17Free Radical ScavengersIBA
11/2023 - 11/2003
17Tissue Plasminogen Activator (Alteplase)FDA Link
10/2020 - 11/2008
15LipidsIBA
01/2018 - 11/2002
11Telmisartan (Micardis)FDA Link
06/2015 - 07/2014
11Atorvastatin (Lipitor)FDA Link
03/2013 - 03/2005
10Superoxide Dismutase-1IBA
01/2015 - 11/2003
9Therapeutic UsesIBA
03/2024 - 09/2008
9salicylhydroxamic acid (SHAM)IBA
05/2020 - 02/2003
8Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2020 - 11/2003
8Galantamine (Galanthamine)FDA LinkGeneric
06/2019 - 04/2013
8Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
01/2016 - 11/2003
8ApolipoproteinsIBA
10/2014 - 08/2003
8CholesterolIBA
10/2014 - 11/2002
7AntioxidantsIBA
03/2024 - 07/2007
7Cilostazol (Pletal)FDA LinkGeneric
02/2021 - 06/2012
7UbiquitinIBA
01/2021 - 10/2002
7Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
06/2020 - 03/2005
7Biomarkers (Surrogate Marker)IBA
01/2020 - 05/2002
7Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2020 - 01/2011
7DNA (Deoxyribonucleic Acid)IBA
12/2018 - 11/2003
7Granulocyte Colony-Stimulating Factor (G-CSF)IBA
06/2016 - 05/2007
7Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
03/2016 - 04/2005
7Apolipoproteins E (ApoE)IBA
10/2014 - 08/2003
7Amlodipine (Norvasc)FDA LinkGeneric
03/2013 - 10/2007
6Warfarin (Coumadin)FDA LinkGeneric
01/2022 - 04/2013
6CollagenIBA
01/2021 - 07/2011
6Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
01/2020 - 12/2007
64-hydroxy-2-nonenal (4-hydroxynonenal)IBA
11/2019 - 03/2005
6CalciumIBA
08/2018 - 06/2002
6SteroidsIBA
01/2018 - 12/2004
5Prion ProteinsIBA
12/2022 - 02/2005
5AntibodiesIBA
05/2021 - 07/2008
5Hematoxylin (Haematoxylon)IBA
03/2021 - 02/2003
5Eosine Yellowish-(YS) (Eosin)IBA
03/2021 - 02/2003
5Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
02/2021 - 06/2012
5Peptides (Polypeptides)IBA
01/2021 - 06/2003
5Oxygen (Dioxygen)IBA
06/2020 - 03/2002
5Amyloid beta-PeptidesIBA
02/2020 - 06/2003
5ameroidIBA
10/2019 - 01/2016
5Advanced Glycation End ProductsIBA
08/2018 - 03/2013
5Donepezil (Aricept)FDA LinkGeneric
11/2017 - 01/2015
5Insulin (Novolin)FDA Link
07/2016 - 08/2005
5Matrix Metalloproteinases (MMPs)IBA
03/2015 - 06/2011
5LDL Receptors (LDL Receptor)IBA
10/2014 - 04/2005
5pitavastatin (itavastatin)FDA Link
03/2013 - 03/2005
4EnzymesIBA
05/2023 - 11/2003
4Alprostadil (Muse)FDA LinkGeneric
01/2023 - 10/2020
4RivaroxabanIBA
01/2022 - 08/2014
4Proteasome Endopeptidase Complex (Proteasome)IBA
01/2021 - 10/2016
4Immunoglobulin G (IgG)IBA
10/2020 - 01/2017
4Reactive Oxygen Species (Oxygen Radicals)IBA
08/2020 - 01/2011
4Intravenous Immunoglobulins (IVIG)FDA Link
06/2020 - 02/2016
4Adrenal Cortex Hormones (Corticosteroids)IBA
02/2020 - 01/2002
4Twendee XIBA
10/2019 - 06/2017

Therapy/Procedure

60Therapeutics
03/2024 - 01/2002
13Activities of Daily Living (ADL)
12/2019 - 06/2012
8Catheters
11/2015 - 02/2003
7Transplantation
01/2023 - 04/2008
6Drug Therapy (Chemotherapy)
10/2021 - 01/2007
5Thrombolytic Therapy
01/2014 - 11/2008